Pumpkin seeds, like all
edible seeds,
pack an immense nutritional and medicinal punch. After all, they
contain future worlds within their compact structure. As Emerson said,
"the creation of a thousand forests is within one acorn."
In order to prepare their "babies" for survival outside the pumpkin,
Nature equips these seeds with an extremely dense source of
organically-bound nutrients, including exceptionally high levels of key,
health-promoting minerals.
For example, a one cup serving (64 grams) of
pumpkin seeds
has 44% daily value (DV) of zinc, 22% of copper, 42% magnesium, 16%
manganese, 17% potassium, and enough iron (17% DV) to improve
iron-deficiency associated anemia.
But beyond the obvious nutritional virtues of the seed, recent
scientific investigations have revealed that pumpkin seed meal, as well
as its pressed oil, may have great value in alleviating the following
conditions:
Prostate Growth: pumpkin seed has been studied for its ability to inhibit
testosterone-induced prostate growth, a common causative factor in benign prostatic hyperplasia.
[i] [ii]
Postmenopausal Symptoms: Women supplemented with 2,000 mg of
pumpkin seed oil
over the course of 12 weeks were found to have reduced blood pressure,
increased HDL cholesterol, as well as reduction in the severity of
hormone insufficiency associated symptoms, e.g. hot flash, headaches and
join pain.
[iii]
Additional experimental research indicates that adverse cardiovascular
changes associated with estrogen deficiency, such as blood pressure and
lipid abnormalities, can be mitigated with pumpkin seed oil.
[iv]
Calcium-Oxalate Kidney Stones: According to a study performed in 1987 and published in the
American Journal of Clinical Nutrition, children with
calcium-oxalate crystals in their urine responded favorably to the supplementation of their diet with pumpkin seeds.
[v]
Cardiovascular and Liver Disease: A mixture of
flaxseed and pumpkin seed was found to have heart-protective and liver-protective properties in an animal study from 2008 published in the
Journal of Food Chemistry & Toxicology.
[vi]
Drug & Chemical Toxicity: The protein isolate of pumpkin seed has been shown to alleviate acetaminophen (Tylenol)
toxicity on the liver,
[vii] and as methotrexate-induced small intestine damage in an animal model.
[viii] It has also been studied to protect against
carbon tetrachloride-induced liver injury.
[ix]
Arthritis: Pumpkin seed oil was found to compare favorably
with the NSAID drug indomethacin in an experimental model of arthritis,
but without causing liver damage, in a study published in 1995 in the
journal of
Pharmacological Research.
[x]
Hypertension: Animals fed pumpkin seed oil were found to
respond more favorably to conventional drug-treatment with
Ace-inhibitors and Calcium Channel Blockers, likely because of its
beneficial antioxidant properties.
[xi]
Parasites: A preclinical canine study has shown that pumpkin seeds have significant activity against
canine intestinal parasites.
[xii]
Insomnia/Anxiety: Pumpkin seeds contain a
high level of tryptophan
(22mg/gram of pumpkin seed protein), the amino acid precursor to
serotonin – which is itself converted to melatonin, the "sleep hormone,"
in the evening. Research published in 2007 in the
Canadian Journal of Physiology and Pharmacology
found that when de-oiled pumpkin seed was taken in combination with
glucose, a clinical effect similar to that of pharmaceutical-grade
tryptophan was achieved.
[xiii] A 2005 study published in the journal
Nutritional Neuroscience found that pumpkin seed sourced tryptophan in combination with carbohydrate was as effective as pharmaceutical tryptophan in
reducing awake time during the night.
These, of course, are only some of the experimentally confirmed
beneficial properties of pumpkin seed. Like all foods, there are likely
countless properties which within the right context, the right timing,
and the right amount, fulfill Hippocrates’ age-old and timelessly true
proclamation that food can be our medicine.
Sayer Ji is the founder of
GreenMedInfo.com. His writings and research have been published in the
Wellbeing Journal, the Journal of Gluten Sensitivity, and have been
featured on numerous websites, including Mercola.com, NaturalNews.com,
Reuters.com, GaryNull.com, and Care2.com.
Disclaimer:
This article is not intended to provide medical advice, diagnosis or
treatment. Views expressed here do not necessarily reflect those of
GreenMedInfo or its staff.
[i]
Inhibition of testosterone-induced hyperplasia of the prostate of
sprague-dawley rats by pumpkin seed oil. QJM. 2008 Mar;101(3):167-79.
Epub 2008 Jan 25. PMID:
16822218
[ii] Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced
prostate growth in rats. Urol Int. 2006;77(3):269-74. PMID:
17033217
[iii]
Improvement in HDL cholesterol in postmenopausal women supplemented
with pumpkin seed oil: pilot study. Climacteric. 2011 May 5. Epub 2011
May 5. PMID:
21545273
[iv] Supplementation with pumpkin seed oil
improves plasma lipid profile and cardiovascular outcomes of female
non-ovariectomized and ovariectomized Sprague-Dawley rats. Phytother
Res. 2008 Jul;22(7):873-7. PMID:
18567058
[v]
The effect of pumpkin seeds on oxalcrystalluria and urinary
compositions of children in hyperendemic area. Am J Clin Nutr. 1987
Jan;45(1):115-21. PMID:
3799495
[vi]
Hypolipidemic and hepatoprotective effects of flax and pumpkin seed
mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic
rats. Food Chem Toxicol. 2008 Dec;46(12):3714-20. Epub 2008 Oct 1. PMID:
18938206
[vii]
In Vitro antioxidative activity of pumpkin seed (Cucurbita pepo)
protein isolate and its In Vivo effect on alanine transaminase and
aspartate transaminase in acetaminophen-induced liver injury in low
protein fed rats. Phytother Res. 2006 Sep ;20(9):780-3. PMID:
16807884
[viii] Protective effect of ellagic acid and pumpkin seed oil against
methotrexate-induced small intestine damage in rats. Indian J Biochem Biophys. 2011 Dec ;48(6):380-7. PMID:
22329239
[ix]
Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity
levels of certain plasma enzymes in CCl4-induced liver injury in
low-protein fed rats. Phytother Res. 2005 Apr ;19(4):341-5. PMID:
16041732
[x] Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats. Pharmacol Res. 1995 Jan;31(1):73-9. PMID:
7784309
[xii]
[Preclinical studies of cucurbita maxima (pumpkin seeds) a traditional
intestinal antiparasitic in rural urban areas]. Rev Gastroenterol Peru.
2004 Oct-Dec;24(4):323-7. PMID:
15614300
[xiii]
Protein-source tryptophan as an efficacious treatment for social
anxiety disorder: a pilot study. Can J Physiol Pharmacol. 2007
Sep;85(9):928-32. PMID:
18066139